Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.

نویسندگان

  • Hironobu Yasui
  • Ryo Takeuchi
  • Masaki Nagane
  • Shunsuke Meike
  • Yoshinari Nakamura
  • Tohru Yamamori
  • Yoshinori Ikenaka
  • Yasuhiro Kon
  • Hiroki Murotani
  • Motoi Oishi
  • Yukio Nagasaki
  • Osamu Inanami
چکیده

High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed to determine the radiosensitizing potential of PEGylated nanogel containing gold nanoparticles (GNG) and the cellular mechanism involved. GNG pretreatment increased the levels of reproductive cell death and apoptosis induced by X-irradiation. GNG accumulated in cytoplasm and increased the expression of endoplasmic reticulum (ER) stress-related protein. GNG suppressed the repair capacity of DNA after X-irradiation by down-regulating DNA repair-related proteins. Our results suggest that GNG radiosensitized cells by enhancing apoptosis and impairing DNA repair capacity via ER stress induction.

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عنوان ژورنال:
  • Cancer letters

دوره 347 1  شماره 

صفحات  -

تاریخ انتشار 2014